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Target
Protein E6
Ligand
BDBM7460
Substrate
n/a
Meas. Tech.
ChEMBL_811818 (CHEMBL2014495)
IC50
>20000±n/a nM
Citation
 Yuan, CH; Filippova, M; Tungteakkhun, SS; Duerksen-Hughes, PJ; Krstenansky, JL Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. Bioorg Med Chem Lett 22:2125-9 (2012) [PubMed]  Article 
Target
Name:
Protein E6
Synonyms:
E6 | VE6_HPV16
Type:
PROTEIN
Mol. Mass.:
19201.73
Organism:
Human papillomavirus type 16
Description:
ChEMBL_811818
Residue:
158
Sequence:
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
  
Inhibitor
Name:
BDBM7460
Synonyms:
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate | CHEMBL50 | Quercetin | Quercetin (10) | Quercetin (21) | Quercetin (Qur) | US11021454, Compound Quercetin | US9180183, Quercetin | med.21724, Compound 4
Type:
Small organic molecule
Emp. Form.:
C15H10O7
Mol. Mass.:
302.2357
SMILES:
Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Structure:
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