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Target
ATP-dependent RNA helicase DDX3X
Ligand
BDBM50379306
Substrate
n/a
Meas. Tech.
ChEMBL_811954 (CHEMBL2013324)
IC50
>1000000±n/a nM
Citation
 Radi, M; Falchi, F; Garbelli, A; Samuele, A; Bernardo, V; Paolucci, S; Baldanti, F; Schenone, S; Manetti, F; Maga, G; Botta, M Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors. Bioorg Med Chem Lett 22:2094-8 (2012) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX3X
Synonyms:
DBX | DDX3 | DDX3X | DDX3X_HUMAN
Type:
PROTEIN
Mol. Mass.:
73247.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811954
Residue:
662
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
  
Inhibitor
Name:
BDBM50379306
Synonyms:
CHEMBL2011806
Type:
Small organic molecule
Emp. Form.:
C26H21N3
Mol. Mass.:
375.465
SMILES:
Cc1[nH]c2ccccc2c1C1=CC(=NN=C(C1)c1ccccc1)c1ccccc1 |c:14,16,t:12|
Structure:
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