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TargetAxin-2
LigandBDBM50318567
Substrate/Competitorn/a
Meas. Tech.ChEMBL_813160
EC50 371±n/a nM
Citation Shultz, MDKirby, CAStams, TChin, DNBlank, JCharlat, OCheng, HCheung, ACong, FFeng, YFortin, PDHood, TTyagi, VXu, MZhang, BShao, W [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem55:1127-36 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Axin-2
Name:Axin-2
Synonyms:AXIN2 | Axil | Axin-like protein | Axis inhibition protein 2 | Conductin
Type:PROTEIN
Mol. Mass.:93575.69
Organism:Homo sapiens
Description:ChEMBL_813160
Residue:843
Sequence:
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
RID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50318567
n/a
NameBDBM50318567
Synonyms:2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol | CHEMBL1086580
TypeSmall organic molecule
Emp. Form.C14H11F3N2OS
Mol. Mass.312.31
SMILESFC(F)(F)c1ccc(cc1)-c1nc2CCSCc2c(=O)[nH]1
Structure
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