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Target
Axin-2
Ligand
BDBM50380590
Substrate
n/a
Meas. Tech.
ChEMBL_813160 (CHEMBL2020826)
EC50
709±n/a nM
Citation
 Shultz, MD; Kirby, CA; Stams, T; Chin, DN; Blank, J; Charlat, O; Cheng, H; Cheung, A; Cong, F; Feng, Y; Fortin, PD; Hood, T; Tyagi, V; Xu, M; Zhang, B; Shao, W [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem 55:1127-36 (2012) [PubMed]  Article 
Target
Name:
Axin-2
Synonyms:
AXIN2 | AXIN2_HUMAN | Axil | Axin-like protein | Axis inhibition protein 2 | Conductin
Type:
PROTEIN
Mol. Mass.:
93575.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_813160
Residue:
843
Sequence:
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
  
Inhibitor
Name:
BDBM50380590
Synonyms:
CHEMBL1898239
Type:
Small organic molecule
Emp. Form.:
C20H19N5O3S
Mol. Mass.:
409.462
SMILES:
COc1ccc(cc1)-c1noc(CSc2nnc(C)n2-c2ccc(OC)cc2)n1
Structure:
Search PDB for entries with ligand similarity: