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TargetPlasminogen
LigandBDBM50380628
Substrate/Competitorn/a
Meas. Tech.ChEMBL_813172
Ki 530±n/a nM
Citation Saupe, SMSteinmetzer, T A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem55:1171-80 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Plasminogen
Name:Plasminogen
Synonyms:Activation peptide | Angiostatin | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:Enzyme
Mol. Mass.:90579.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT
CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN
GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE
CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE
LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS
AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE
QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG
LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED
CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG
PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT
RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ
LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW
GLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50380628
NameBDBM50380628
Synonyms:CHEMBL2016876
TypeSmall organic molecule
Emp. Form.C31H46N4O3
Mol. Mass.522.7219
SMILESCCCCCCCCNC(=O)[C@@H](Cc1ccc(OCc2ccncc2)cc1)NC(=O)[C@H]1CC[C@H](CN)CC1 |r,wU:11.28,33.35,wD:30.31,(18.44,-28.09,;19.77,-28.86,;21.11,-28.09,;22.44,-28.86,;23.77,-28.09,;25.11,-28.86,;26.44,-28.09,;27.77,-28.86,;29.11,-28.09,;30.44,-28.86,;30.44,-30.4,;31.78,-28.09,;31.78,-26.55,;30.44,-25.78,;30.45,-24.24,;29.11,-23.47,;27.78,-24.24,;26.44,-23.47,;25.11,-24.25,;23.78,-23.48,;23.78,-21.94,;22.45,-21.17,;21.11,-21.94,;21.12,-23.49,;22.45,-24.25,;27.78,-25.79,;29.12,-26.55,;33.11,-28.86,;34.44,-28.09,;34.44,-26.55,;35.78,-28.86,;35.77,-30.4,;37.09,-31.17,;38.43,-30.4,;39.76,-31.18,;39.75,-32.72,;38.43,-28.86,;37.1,-28.08,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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