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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50382891
Substrate
n/a
Meas. Tech.
ChEMBL_815280 (CHEMBL2026495)
IC50
495±n/a nM
Citation
 Graham, TH; Liu, W; Verras, A; Sebhat, IK; Xiong, Y; Bleasby, K; Bhatt, UR; Chen, Q; Garcia-Calvo, M; Geissler, WM; Gorski, JN; He, H; Lassman, ME; Lisnock, J; Li, X; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xiao, J; Xie, D; Xu, S; Hale, JJ; Pinto, S; Shen, DM A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorg Med Chem Lett 22:2811-7 (2012) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mus musculus
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50382891
Synonyms:
CHEMBL2024200
Type:
Small organic molecule
Emp. Form.:
C30H36ClF2N5O
Mol. Mass.:
556.09
SMILES:
Cc1nc(nn1-c1ccc(Cl)c(C)c1)C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r|
Structure:
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