Target
Adenosine receptor A2b
Ligand
BDBM50083917
Substrate
n/a
Meas. Tech.
ChEMBL_818429 (CHEMBL2034749)
IC50
58±n/a nM
Citation
 Taliani, SPugliesi, IBarresi, ESimorini, FSalerno, SLa Motta, CMarini, AMCosimelli, BCosconati, SDi Maro, SMarinelli, LDaniele, STrincavelli, MLGreco, GNovellino, EMartini, CDa Settimo, F 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. J Med Chem 55:1490-9 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50083917
Synonyms:
10-methyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one | CHEMBL7909
Type:
Small organic molecule
Emp. Form.:
C16H12N4O
Mol. Mass.:
276.2927
SMILES:
Cn1c2ccccc2n2c1nnc(-c1ccccc1)c2=O
Structure:
Search PDB for entries with ligand similarity: