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Target
Adenosine receptor A1
Ligand
BDBM50102284
Substrate
n/a
Meas. Tech.
ChEMBL_818427 (CHEMBL2034747)
Ki
299±n/a nM
Citation
 Taliani, S; Pugliesi, I; Barresi, E; Simorini, F; Salerno, S; La Motta, C; Marini, AM; Cosimelli, B; Cosconati, S; Di Maro, S; Marinelli, L; Daniele, S; Trincavelli, ML; Greco, G; Novellino, E; Martini, C; Da Settimo, F 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. J Med Chem 55:1490-9 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50102284
Synonyms:
10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one | CHEMBL326752
Type:
Small organic molecule
Emp. Form.:
C22H16N4O
Mol. Mass.:
352.3886
SMILES:
O=c1c(nnc2n(Cc3ccccc3)c3ccccc3n12)-c1ccccc1
Structure:
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