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Target
Glycylpeptide N-tetradecanoyltransferase 2
Ligand
BDBM50384914
Substrate
n/a
Meas. Tech.
ChEMBL_820573 (CHEMBL2040310)
Ki
11390±n/a nM
Citation
 Goncalves, V; Brannigan, JA; Whalley, D; Ansell, KH; Saxty, B; Holder, AA; Wilkinson, AJ; Tate, EW; Leatherbarrow, RJ Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. J Med Chem 55:3578-82 (2012) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 2
Synonyms:
Glycylpeptide N-tetradecanoyltransferase 2 | Myristoyl-CoA:protein N-myristoyltransferase 2 | NMT 2 | NMT2 | NMT2_HUMAN | Peptide N-myristoyltransferase 2 | Type II N-myristoyltransferase
Type:
PROTEIN
Mol. Mass.:
56986.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435042
Residue:
498
Sequence:
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
  
Inhibitor
Name:
BDBM50384914
Synonyms:
CHEMBL2036496 | CHEMBL2079453
Type:
Small organic molecule
Emp. Form.:
C18H22N2OS
Mol. Mass.:
314.445
SMILES:
CCCCc1c(C)nc2ccc(OC)cc2c1SCCC#N
Structure:
Search PDB for entries with ligand similarity: