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Target
Cathepsin L2
Ligand
BDBM48563
Substrate
n/a
Meas. Tech.
ChEMBL_825258 (CHEMBL2043890)
IC50
4700±n/a nM
Citation
 Marques, EF; Bueno, MA; Duarte, PD; Silva, LR; Martinelli, AM; dos Santos, CY; Severino, RP; Brömme, D; Vieira, PC; Corrêa, AG Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V. Eur J Med Chem 54:10-21 (2012) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM48563
Synonyms:
2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone | 2-phenylquinolin-4-ol | CHEMBL277148 | MLS000084697 | SMR000019044 | cid_161091
Type:
Small organic molecule
Emp. Form.:
C15H11NO
Mol. Mass.:
221.2539
SMILES:
Oc1cc(nc2ccccc12)-c1ccccc1
Structure:
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