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Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM50386307
Substrate
n/a
Meas. Tech.
ChEMBL_826598 (CHEMBL2050766)
IC50
174±n/a nM
Citation
 Dounay, AB; Anderson, M; Bechle, BM; Campbell, BM; Claffey, MM; Evdokimov, A; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Hayward, MM; Horner, W; Kim, JY; McAllister, LA; Pandit, J; Paradis, V; Parikh, VD; Reese, MR; Rong, S; Salafia, MA; Schuyten, K; Strick, CA; Tuttle, JB; Valentine, J; Wang, H; Zawadzke, LE; Verhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM50386307
Synonyms:
CHEMBL2047860
Type:
Small organic molecule
Emp. Form.:
C10H9F3N2O2
Mol. Mass.:
246.1859
SMILES:
N[C@H]1Cc2cccc(c2N(O)C1=O)C(F)(F)F |r|
Structure:
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