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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50386932
Substrate
n/a
Meas. Tech.
ChEMBL_827456 (CHEMBL2051313)
EC50
9±n/a nM
Citation
 Lee, SC; Kim, HT; Park, CH; Lee, do Y; Chang, HJ; Park, S; Cho, JM; Ro, S; Suh, YG Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3ß inhibitors. Bioorg Med Chem Lett 22:4221-4 (2012) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50386932
Synonyms:
CHEMBL2048677
Type:
Small organic molecule
Emp. Form.:
C19H14FN5O2
Mol. Mass.:
363.3452
SMILES:
COc1ccncc1NC(=O)c1ccnc2nc([nH]c12)-c1ccc(F)cc1
Structure:
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