Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM50387117
Substrate
n/a
Meas. Tech.
ChEMBL_827865 (CHEMBL2051274)
Ki
3±n/a nM
Citation
 Winum, JY; Carta, F; Ward, C; Mullen, P; Harrison, D; Langdon, SP; Cecchi, A; Scozzafava, A; Kunkler, I; Supuran, CT Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines. Bioorg Med Chem Lett 22:4681-5 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50387117
Synonyms:
4-ureidophenyl sulfamate ring derivative 3g | CHEMBL2047802
Type:
Small organic molecule
Emp. Form.:
C14H15N3O5S
Mol. Mass.:
337.351
SMILES:
COc1ccc(NC(=O)Nc2ccc(OS(N)(=O)=O)cc2)cc1
Structure:
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