Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50092660
Substrate
n/a
Meas. Tech.
ChEMBL_827952 (CHEMBL2051531)
Ki
8900±n/a nM
Citation
 Karle, M; Knecht, W; Xue, Y Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. Bioorg Med Chem Lett 22:4839-43 (2012) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50092660
Synonyms:
4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL124632 | CHEMBL545184 | US11584714, Compound 47a | p-aminobenzamidine
Type:
Small organic molecule
Emp. Form.:
C7H9N3
Mol. Mass.:
135.1665
SMILES:
NC(=N)c1ccc(N)cc1
Structure:
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