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Target
Histamine H4 receptor
Ligand
BDBM50133018
Substrate
n/a
Meas. Tech.
ChEMBL_828300 (CHEMBL2050319)
Ki
6.31±n/a nM
Citation
 Engelhardt, H; de Esch, IJ; Kuhn, D; Smits, RA; Zuiderveld, OP; Dobler, J; Mayer, M; Lips, S; Arnhof, H; Scharn, D; Haaksma, EE; Leurs, R Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands. Eur J Med Chem 54:660-8 (2012) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50133018
Synonyms:
(4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (4,5-dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL129436
Type:
Small organic molecule
Emp. Form.:
C14H15Cl2N3O
Mol. Mass.:
312.194
SMILES:
CN1CCN(CC1)C(=O)c1cc2c(Cl)c(Cl)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: