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TargetPeripheral-Type Benzodiazepine Receptor
LigandBDBM50388424
Substrate/Competitorn/a
Meas. Tech.ChEMBL_829916
Ki 1.55±n/a nM
Citation Castellano, STaliani, SMilite, CPugliesi, IDa Pozzo, ERizzetto, EBendinelli, SCosta, BCosconati, SGreco, GNovellino, ESbardella, GStefancich, GMartini, CDa Settimo, F Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J Med Chem55:4506-10 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peripheral-Type Benzodiazepine Receptor
Name:Benzodiazepine receptors; peripheral & central
Synonyms:Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR)
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50388424
NameBDBM50388424
Synonyms:CHEMBL2059062
TypeSmall organic molecule
Emp. Form.C20H20ClN3O
Mol. Mass.353.845
SMILESCC[C@@H](C)N(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1 |r|
Structure
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