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Target
Dynamin-1
Ligand
BDBM50388827
Substrate
n/a
Meas. Tech.
ChEMBL_831002 (CHEMBL2065654)
IC50
18100±n/a nM
Citation
 Robertson, MJ; Hadzic, G; Ambrus, J; Pomè, DY; Hyde, E; Whiting, A; Mariana, A; von Kleist, L; Chau, N; Haucke, V; Robinson, PJ; McCluskey, A The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. ACS Med Chem Lett 3:352-356 (2012) [PubMed]  Article 
Target
Name:
Dynamin-1
Synonyms:
DNM | DNM1 | DYN1_HUMAN | Dynamin-1
Type:
PROTEIN
Mol. Mass.:
97411.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458576
Residue:
864
Sequence:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL
  
Inhibitor
Name:
BDBM50388827
Synonyms:
CHEMBL2062731
Type:
Small organic molecule
Emp. Form.:
C10H5Cl2NOS2
Mol. Mass.:
290.189
SMILES:
SC1=NC(=O)C(S1)=Cc1cc(Cl)cc(Cl)c1 |w:7.8,t:1|
Structure:
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