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Target
Probable G-protein coupled receptor 142
Ligand
BDBM50390586
Substrate
n/a
Meas. Tech.
ChEMBL_835424 (CHEMBL2072130)
EC50
4600±n/a nM
Citation
 Lizarzaburu, M; Turcotte, S; Du, X; Duquette, J; Fu, A; Houze, J; Li, L; Liu, J; Murakoshi, M; Oda, K; Okuyama, R; Nara, F; Reagan, J; Yu, M; Medina, JC Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett 22:5942-7 (2012) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM50390586
Synonyms:
CHEMBL2069491
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2
Mol. Mass.:
359.3813
SMILES:
N[C@@H](Cc1ccc(cc1)C#N)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Structure:
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