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TargetProbable G-protein coupled receptor 142
LigandBDBM50390587
Substrate/Competitorn/a
Meas. Tech.ChEMBL_835424
EC50 6600±n/a nM
Citation Lizarzaburu, MTurcotte, SDu, XDuquette, JFu, AHouze, JLi, LLiu, JMurakoshi, MOda, KOkuyama, RNara, FReagan, JYu, MMedina, JC Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett22:5942-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Probable G-protein coupled receptor 142
Name:Probable G-protein coupled receptor 142
Synonyms:G-protein coupled receptor PGR2 | GPR142 | PGR2
Type:PROTEIN
Mol. Mass.:51127.50
Organism:Homo sapiens (Human)
Description:ChEMBL_985961
Residue:462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50390587
NameBDBM50390587
Synonyms:CHEMBL2069492
TypeSmall organic molecule
Emp. Form.C20H20N4O2
Mol. Mass.348.3984
SMILESCc1ccc(C[C@H](N)C(=O)Nc2cc(c[nH]c2=O)-c2ccncc2)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a