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Target
Dipeptidyl peptidase 4
Ligand
BDBM50391474
Substrate
n/a
Meas. Tech.
ChEMBL_849436 (CHEMBL2149437)
IC50
676±n/a nM
Citation
 Ikuma, Y; Hochigai, H; Kimura, H; Nunami, N; Kobayashi, T; Uchiyama, K; Furuta, Y; Sakai, M; Horiguchi, M; Masui, Y; Okazaki, K; Sato, Y; Nakahira, H Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem 20:5864-83 (2012) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
ACT3 | ADCP-I | Activation molecule 3 | Adenosine deaminase complexing protein | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_BOVIN | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 | WC10
Type:
PROTEIN
Mol. Mass.:
88365.89
Organism:
Bos taurus
Description:
ChEMBL_849436
Residue:
765
Sequence:
MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLRWVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSPSQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLCDVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNEYKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYTLHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYPLLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL
  
Inhibitor
Name:
BDBM50391474
Synonyms:
CHEMBL2147197
Type:
Small organic molecule
Emp. Form.:
C15H22N6O2
Mol. Mass.:
318.3742
SMILES:
CC(C)=CCn1c(nc2n(C)c(=O)[nH]c(=O)c12)N1CCNCC1 |(-.09,4.19,;-1.46,3.49,;-2.76,4.33,;-1.54,1.94,;-2.92,1.24,;-3,-.31,;-2.06,-1.52,;-2.92,-2.8,;-4.4,-2.36,;-5.7,-3.17,;-5.65,-4.72,;-7.05,-2.44,;-8.37,-3.26,;-7.1,-.91,;-5.8,-.11,;-5.84,1.44,;-4.45,-.83,;-.52,-1.47,;.29,-2.78,;1.83,-2.73,;2.55,-1.37,;1.75,-.07,;.21,-.11,)|
Structure:
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