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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50391949
Substrate
n/a
Meas. Tech.
ChEMBL_849985 (CHEMBL2149642)
IC50
92±n/a nM
Citation
 Nakano, H; Saito, N; Parker, L; Tada, Y; Abe, M; Tsuganezawa, K; Yokoyama, S; Tanaka, A; Kojima, H; Okabe, T; Nagano, T Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. J Med Chem 55:5151-64 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50391949
Synonyms:
CHEMBL2147768
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3
Mol. Mass.:
390.4351
SMILES:
COc1ccc2C(=O)\C(Oc2c1CN1CCNCC1)=C\c1c[nH]c2cnccc12
Structure:
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