Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50190795
Substrate
n/a
Meas. Tech.
ChEMBL_851151 (CHEMBL2157808)
EC50
100±n/a nM
Citation
 Mazurov, AA; Speake, JD; Yohannes, D Discovery and development ofa7 nicotinic acetylcholine receptor modulators. J Med Chem 54:7943-61 (2011) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50190795
Synonyms:
(R)-N-(quinuclidin-3-yl)-1H-indole-6-carboxamide | CHEMBL212669
Type:
Small organic molecule
Emp. Form.:
C16H19N3O
Mol. Mass.:
269.3416
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1ccc2cc[nH]c2c1 |wU:3.2,(11.41,4.23,;11.42,2.69,;12.75,1.92,;14.08,2.7,;14.07,4.23,;15.41,5.01,;16.75,4.24,;16.75,2.7,;15.42,1.93,;14.54,3.07,;15.36,3.87,;10.09,1.91,;10.09,.36,;8.75,-.42,;7.42,.35,;5.95,-.12,;5.05,1.13,;5.96,2.37,;7.42,1.89,;8.74,2.67,)|
Structure:
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