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Target
Presenilin-2
Ligand
BDBM50393455
Substrate
n/a
Meas. Tech.
ChEMBL_855576 (CHEMBL2163022)
IC50
16±n/a nM
Citation
 Wu, WL; Domalski, M; Burnett, DA; Josien, H; Bara, T; Rajagopalan, M; Xu, R; Clader, J; Greenlee, WJ; Brunskill, A; Hyde, LA; Del Vecchio, RA; Cohen-Williams, ME; Song, L; Lee, J; Terracina, G; Zhang, Q; Nomeir, A; Parker, EM; Zhang, L Discovery of SCH 900229, a Potent Presenilin 1 Selective ¿-Secretase Inhibitor for the Treatment of Alzheimer's Disease. ACS Med Chem Lett 3:892-896 (2012) [PubMed]  Article 
Target
Name:
Presenilin-2
Synonyms:
AD3LP | AD4 | AD5 | E5-1 | Gamma-secretase | PS-2 | PS2 | PSEN2 | PSN2_HUMAN | PSNL2 | Presenilin 2 | Presenilin-2 | Presenilin-2 CTF subunit | Presenilin-2 NTF subunit | STM-2 | STM2
Type:
PROTEIN
Mol. Mass.:
50116.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_855576
Residue:
448
Sequence:
MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
  
Inhibitor
Name:
BDBM50393455
Synonyms:
CHEMBL2159691
Type:
Small organic molecule
Emp. Form.:
C21H18ClF2NO4S
Mol. Mass.:
453.887
SMILES:
Fc1ccc(F)c2c1OC[C@H]1[C@H](CCC#N)OCC[C@@]21S(=O)(=O)c1ccc(Cl)cc1 |r|
Structure:
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