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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A
LigandBDBM50240404
Substrate/Competitorn/a
Meas. Tech.ChEMBL_856427
EC50 900±n/a nM
Citation Day, JPLindsay, BRiddell, TJiang, ZAllcock, RWAbraham, ASookup, SChristian, FBogum, JMartin, EKRae, RLAnthony, DRosair, GMHouslay, DMHuston, EBaillie, GSKlussmann, EHouslay, MDAdams, DR Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem54:3331-47 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Synonyms:PDE46 | PDE4A | Phosphodiesterase 4A (PDE4) | cAMP-specific 3 ,5 -cyclic phosphodiesterase 4A | cAMP-specific 3,5-cyclic phosphodiesterase 4A
Type:Enzyme
Mol. Mass.:98113.27
Organism:Homo sapiens (human)
Description:P27815
Residue:886
Sequence:
MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50240404
NameBDBM50240404
Synonyms:(Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-2-methyl-propan-1-one | 1-(2-isopropylH-pyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one | CHEMBL19449 | IBUDILAST
TypeSmall organic molecule
Emp. Form.C14H18N2O
Mol. Mass.230.3055
SMILESCC(C)C(=O)c1c(nn2ccccc12)C(C)C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a