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Target
Monoglyceride lipase
Ligand
BDBM50393691
Substrate
n/a
Meas. Tech.
ChEMBL_856311 (CHEMBL2160518)
IC50
3019.95±n/a nM
Citation
 Kapanda, CN; Masquelier, J; Labar, G; Muccioli, GG; Poupaert, JH; Lambert, DM Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors. J Med Chem 55:5774-83 (2012) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50393691
Synonyms:
CHEMBL2158925
Type:
Small organic molecule
Emp. Form.:
C11H11N3O4S2
Mol. Mass.:
313.353
SMILES:
[O-][N+](=O)c1ccc(SC(=S)N2CCCC2)c(c1)[N+]([O-])=O
Structure:
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