Target
Aurora kinase B
Ligand
BDBM50394792
Substrate
n/a
Meas. Tech.
ChEMBL_859400 (CHEMBL2167306)
Kd
3.2±n/a nM
Citation
 Liu, GAbraham, STran, LVickers, TDXu, SHadd, MJQuiambao, SHolladay, MWHua, HFord Pulido, JMGunawardane, RNDavis, MIEichelberger, SRApuy, JLGitnick, DGardner, MFJames, JBreider, MABelli, BArmstrong, RCTreiber, DK Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index. J Med Chem 55:3250-60 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50394792
Synonyms:
CHEMBL2163396
Type:
Small organic molecule
Emp. Form.:
C23H27N9O3S2
Mol. Mass.:
541.649
SMILES:
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C4)NS(C)(=O)=O)cc3)nn3cccc23)n[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: