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TargetGlucocerebrosidase (Acid beta-Glucosidase)
LigandBDBM18358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_860090
Ki 300±n/a nM
Citation Trapero, AGonzález-Bulnes, PButters, TDLlebaria, A Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. J Med Chem55:4479-88 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucocerebrosidase (Acid beta-Glucosidase)
Name:Beta-glucocerebrosidase
Synonyms:β-glucocerebrosidase (GCase) | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase). | Imiglucerase
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18358
NameBDBM18358
Synonyms:(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol | N-Nonyl-DNJ
TypeSmall organic molecule
Emp. Form.C15H31NO4
Mol. Mass.289.4109
SMILESCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure
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n/a
NameBDBM18358
Synonyms:(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol | N-Nonyl-DNJ
TypeSmall organic molecule
Emp. Form.C15H31NO4
Mol. Mass.289.4109
SMILESCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: