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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50395896
Substrate
n/a
Meas. Tech.
ChEMBL_858075 (CHEMBL2166987)
IC50
5.32±n/a nM
Citation
 McAllister, LA; Montgomery, JI; Abramite, JA; Reilly, U; Brown, MF; Chen, JM; Barham, RA; Che, Y; Chung, SW; Menard, CA; Mitton-Fry, M; Mullins, LM; Noe, MC; O'Donnell, JP; Oliver, RM; Penzien, JB; Plummer, M; Price, LM; Shanmugasundaram, V; Tomaras, AP; Uccello, DP Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents. Bioorg Med Chem Lett 22:6832-8 (2012) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
lpxC
Type:
PROTEIN
Mol. Mass.:
21890.40
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_858075
Residue:
197
Sequence:
TVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLL
  
Inhibitor
Name:
BDBM50395896
Synonyms:
CHEMBL2164193
Type:
Small organic molecule
Emp. Form.:
C16H19FN2O6S
Mol. Mass.:
386.395
SMILES:
COc1cccc(-c2cc(CC[C@](C)(C(=O)NO)S(C)(=O)=O)on2)c1F |r|
Structure:
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