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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50395983
Substrate
n/a
Meas. Tech.
ChEMBL_858567 (CHEMBL2166012)
IC50
43.65±n/a nM
Citation
 Poslusney, MS; Sevel, C; Utley, TJ; Bridges, TM; Morrison, RD; Kett, NR; Sheffler, DJ; Niswender, CM; Daniels, JS; Conn, PJ; Lindsley, CW; Wood, MR Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists. Bioorg Med Chem Lett 22:6923-8 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50395983
Synonyms:
CHEMBL2164911
Type:
Small organic molecule
Emp. Form.:
C20H24N2O
Mol. Mass.:
308.4174
SMILES:
CN1CCN(CC1)C(=O)C(Cc1ccccc1)c1ccccc1
Structure:
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