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TargetGlucocerebrosidase (Acid beta-Glucosidase)
LigandBDBM18428
Substrate/Competitorn/a
Meas. Tech.ChEMBL_862810
IC50 30±n/a nM
Citation Patnaik, SZheng, WChoi, JHMotabar, OSouthall, NWestbroek, WLea, WAVelayati, AGoldin, ESidransky, ELeister, WMarugan, JJ Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. J Med Chem55:5734-48 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucocerebrosidase (Acid beta-Glucosidase)
Name:Glucocerebrosidase (Acid beta-Glucosidase)
Synonyms:β-glucocerebrosidase (GCase) | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase). | Imiglucerase
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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  Blast E-value cutoff:
BDBM18428
n/a
NameBDBM18428
Synonyms:Aminoquinoline compound, 1 | N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclohexanecarboxamide | NCGC00092410
TypeSmall organic molecule
Emp. Form.C21H27N3O2
Mol. Mass.353.458
SMILESCc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1
Structure
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