Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50396382
Substrate
n/a
Meas. Tech.
ChEMBL_861906 (CHEMBL2173634)
Ki
13.3±n/a nM
Citation
 Díaz, JLCuberes, RBerrocal, JContijoch, MChristmann, UFernández, APort, AHolenz, JBuschmann, HLaggner, CSerafini, MTBurgueño, JZamanillo, DMerlos, MVela, JMAlmansa, C Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem 55:8211-24 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50396382
Synonyms:
CHEMBL2170221
Type:
Small organic molecule
Emp. Form.:
C18H23Cl2N3O2
Mol. Mass.:
384.3
SMILES:
Cc1cc(OCCCCN2CCOCC2)nn1-c1ccc(Cl)c(Cl)c1
Structure:
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