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TargetGlucose-6-phosphate 1-dehydrogenase
LigandBDBM50396525
Substrate/Competitorn/a
Meas. Tech.ChEMBL_862644
IC50 19700±n/a nM
Citation Preuss, JMaloney, PPeddibhotla, SHedrick, MPHershberger, PGosalia, PMilewski, MLi, YLSugarman, EHood, BSuyama, ENguyen, KVasile, SSergienko, EMangravita-Novo, AVicchiarelli, MMcAnally, DSmith, LHRoth, GPDiwan, JChung, TDJortzik, ERahlfs, SBecker, KPinkerton, ABBode, L Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro. J Med Chem55:7262-72 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucose-6-phosphate 1-dehydrogenase
Name:Glucose-6-phosphate 1-dehydrogenase
Synonyms:PFG6PD
Type:PROTEIN
Mol. Mass.:86360.63
Organism:Plasmodium falciparum
Description:ChEMBL_862647
Residue:736
Sequence:
MNNYQNNYIYNEKTLDFINNDQDNDNLKYLKEYVYFTTTNQFDVRKRITVSLNLLANASS
KIFLLNSKDKLDLWKNMLIKSYIEVNYNLYPATYLIDTSCTNENVNINNNNNNNNKNKNN
YCYSNTTVISCGYENYTKYIEEIYDSKYALSLYSNSLNKEELLTIIIFGCSGDLAKKKIY
PALFKLFCNNSLPKDLLIIGFARTVQDFDTFFDKIVIYLKRCLLCYEDWSISKKKDLLNG
FKNRCRYFVGNYSSSESFENFNKYLTTIEEEEAKKKYYATCYKMNGSDYNISNNVAEDNI
SIDDENKTNEYFQMCTPKNCPDNVFSSNYNFPYVINSILYLALPPHIFISTLKKIIKKNC
LNSKGTDKILLEKPFGNDLDSFKMLSKQILENFNEQQIYRIDHYLGKDMVSGLLKLKFTN
TFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEDPID
LNDESVKNEKIKILKSIPSIKLEDTIIGQYEKAENFKEDENNDDESKKNHSYHDDPHIDK
NSITPTFCTCILYINSINWYGVPIIFKSGKGLNKDICEIRIQFHNIMGSSDENMNNNEFV
IILQPVEAIYLKMMIKKTGCEEMEEVQLNLTVNEKNKKINVPEAYETLLLECFKGHKKKF
ISDEELYESWRIFTPLLKELQEKQVKPLKYSFGSSGPKEVFGLVKKYYNYGKNYTHRPEF
VRKSSFYEDDLLDINY
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BDBM50396525
NameBDBM50396525
Synonyms:CHEMBL2170932
TypeSmall organic molecule
Emp. Form.C23H25N3O2S
Mol. Mass.407.529
SMILESCCN1CCCC1CNC(=O)c1ccc2S\C(=C/c3ccccc3)C(=O)Nc2c1
Structure
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n/a