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TargetCathepsin A (CTSA)
LigandBDBM50396562
Substrate/Competitorn/a
Meas. Tech.ChEMBL_863255
IC50 5±n/a nM
Citation Ruf, SBuning, CSchreuder, HHorstick, GLinz, WOlpp, TPernerstorfer, JHiss, KKroll, KKannt, AKohlmann, MLinz, DHübschle, TRütten, HWirth, KSchmidt, TSadowski, T Novelß-amino acid derivatives as inhibitors of cathepsin A. J Med Chem55:7636-49 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin A (CTSA)
Name:Cathepsin A (CTSA)
Synonyms:Cathepsin A | Lysosomal protective protein
Type:Protein
Mol. Mass.:54465.95
Organism:Homo sapiens (Human)
Description:P10619
Residue:480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50396562
NameBDBM50396562
Synonyms:CHEMBL2171392
TypeSmall organic molecule
Emp. Form.C26H30FN3O5
Mol. Mass.483.5319
SMILESCc1ccccc1[C@H](CC(O)=O)NC(=O)c1cc(OC[C@H](O)C(C)(C)C)n(n1)-c1ccccc1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a