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Target
Lysosomal protective protein
Ligand
BDBM50396583
Substrate
n/a
Meas. Tech.
ChEMBL_863255 (CHEMBL2176198)
IC50
25±n/a nM
Citation
 Ruf, S; Buning, C; Schreuder, H; Horstick, G; Linz, W; Olpp, T; Pernerstorfer, J; Hiss, K; Kroll, K; Kannt, A; Kohlmann, M; Linz, D; Hübschle, T; Rütten, H; Wirth, K; Schmidt, T; Sadowski, T Novelß-amino acid derivatives as inhibitors of cathepsin A. J Med Chem 55:7636-49 (2012) [PubMed]  Article 
Target
Name:
Lysosomal protective protein
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN
Type:
Protein
Mol. Mass.:
54465.95
Organism:
Homo sapiens (Human)
Description:
P10619
Residue:
480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
  
Inhibitor
Name:
BDBM50396583
Synonyms:
CHEMBL2171404
Type:
Small organic molecule
Emp. Form.:
C25H19F2N3O4
Mol. Mass.:
463.4329
SMILES:
OC(=O)CC(NC(=O)c1cc(=O)n([nH]1)-c1ccccc1F)c1ccc(cc1)-c1ccc(F)cc1
Structure:
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