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TargetVasopressin V2 receptor (V2)
LigandBDBM50397211
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864210
Ki 16.8±n/a nM
Citation Loison, SCottet, MOrcel, HAdihou, HRahmeh, RLamarque, LTrinquet, EKellenberger, EHibert, MDurroux, TMouillac, BBonnet, D Selective fluorescent nonpeptidic antagonists for vasopressin V2 GPCR: application to ligand screening and oligomerization assays. J Med Chem55:8588-602 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin V2 receptor (V2)
Name:Vasopressin receptor
Synonyms:AVPR V2 | AVPR2 | Antidiuretic hormone receptor | Renal-type arginine vasopressin receptor | VASOPRESSIN V2 | Vasopressin V2 receptor
Type:Receptor
Mol. Mass.:40295.28
Organism:Homo sapiens (Human)
Description:P30518
Residue:371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50397211
NameBDBM50397211
Synonyms:CHEMBL2172393
TypeSmall organic molecule
Emp. Form.C66H72N6O12S2
Mol. Mass.1205.441
SMILESCCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCOCCOCCOCCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc34)c3ccc(cc3oc2c1)=[N+](CC)CC |(51.81,4.38,;50.27,4.42,;49.46,3.11,;50.2,1.76,;51.74,1.71,;47.92,3.16,;47.12,1.84,;45.58,1.88,;44.86,3.22,;43.41,3.2,;42.63,1.89,;41.08,1.9,;40.29,.58,;41.04,-.76,;42.59,-.79,;43.38,.53,;44.91,.51,;45.66,-.84,;46.41,.91,;44.93,2.06,;40.25,-2.08,;41.58,-2.86,;40.23,-3.62,;38.71,-2.09,;37.95,-3.42,;36.4,-3.43,;35.64,-4.77,;34.1,-4.77,;33.34,-6.11,;31.8,-6.12,;31.03,-7.45,;29.49,-7.46,;28.73,-8.79,;27.19,-8.8,;26.42,-10.14,;24.88,-10.14,;24.11,-8.81,;24.12,-11.48,;24.87,-12.78,;26.41,-12.77,;27.4,-13.96,;27.06,-15.47,;25.66,-16.16,;25.65,-17.73,;24.32,-18.5,;26.98,-18.51,;26.97,-20.05,;28.3,-20.82,;29.64,-20.05,;30.97,-20.82,;32.3,-20.06,;32.31,-18.52,;33.63,-20.83,;33.63,-22.38,;34.96,-23.15,;36.3,-22.38,;36.3,-20.84,;34.96,-20.07,;34.97,-18.53,;36.3,-17.76,;36.3,-16.22,;34.97,-15.45,;33.63,-16.23,;33.63,-17.76,;29.65,-18.52,;28.33,-17.74,;24.28,-15.51,;23.16,-16.59,;21.67,-16.16,;21.29,-14.64,;22.41,-13.56,;23.91,-14,;42.59,4.61,;41.06,4.65,;40.32,5.97,;41.12,7.29,;42.64,7.26,;43.38,5.92,;44.92,5.9,;45.66,4.54,;47.2,4.5,;40.38,8.65,;41.18,9.96,;40.44,11.31,;38.84,8.68,;38.1,10.02,)|
Structure
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