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TargetVasopressin V2 receptor (V2)
LigandBDBM50397212
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864210
Ki 12.7±n/a nM
Citation Loison, SCottet, MOrcel, HAdihou, HRahmeh, RLamarque, LTrinquet, EKellenberger, EHibert, MDurroux, TMouillac, BBonnet, D Selective fluorescent nonpeptidic antagonists for vasopressin V2 GPCR: application to ligand screening and oligomerization assays. J Med Chem55:8588-602 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin V2 receptor (V2)
Name:Vasopressin receptor
Synonyms:AVPR V2 | AVPR2 | Antidiuretic hormone receptor | Renal-type arginine vasopressin receptor | VASOPRESSIN V2 | Vasopressin V2 receptor
Type:Receptor
Mol. Mass.:40295.28
Organism:Homo sapiens (Human)
Description:P30518
Residue:371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50397212
NameBDBM50397212
Synonyms:CHEMBL2172392
TypeSmall organic molecule
Emp. Form.C64H67N7O9S2
Mol. Mass.1142.388
SMILESCCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)N3CCN(CCC(=O)NC4CCCN(C(=O)c5ccc(NC(=O)c6ccccc6-c6ccccc6)cc5)c5ccccc45)CC3)c3ccc(cc3oc2c1)=[N+](CC)CC |(24.73,-1.99,;23.19,-1.95,;22.38,-3.27,;23.12,-4.62,;24.66,-4.66,;20.84,-3.22,;20.04,-4.53,;18.51,-4.48,;17.78,-3.15,;16.34,-3.17,;15.55,-4.49,;14,-4.47,;13.21,-5.79,;13.96,-7.13,;15.51,-7.16,;16.3,-5.84,;17.84,-5.86,;18.58,-7.21,;19.33,-5.47,;17.86,-4.32,;13.17,-8.45,;14.5,-9.22,;13.15,-9.98,;11.63,-8.43,;10.87,-9.77,;9.33,-9.77,;8.56,-8.44,;7.02,-8.45,;6.25,-9.79,;4.71,-9.79,;3.94,-8.46,;3.95,-11.13,;4.7,-12.43,;6.25,-12.42,;7.23,-13.61,;6.9,-15.12,;5.5,-15.81,;5.48,-17.38,;4.15,-18.15,;6.81,-18.16,;6.81,-19.7,;8.14,-20.47,;9.47,-19.7,;10.8,-20.47,;12.13,-19.71,;12.14,-18.17,;13.46,-20.48,;13.46,-22.03,;14.79,-22.8,;16.13,-22.03,;16.13,-20.49,;14.79,-19.72,;14.8,-18.18,;16.13,-17.41,;16.14,-15.87,;14.8,-15.1,;13.46,-15.88,;13.46,-17.41,;9.48,-18.17,;8.16,-17.39,;4.11,-15.16,;3,-16.24,;1.5,-15.81,;1.12,-14.29,;2.25,-13.21,;3.74,-13.64,;9.32,-7.1,;10.87,-7.1,;15.51,-1.75,;13.98,-1.73,;13.24,-.39,;14.04,.93,;15.56,.9,;16.3,-.45,;17.84,-.48,;18.58,-1.84,;20.12,-1.87,;13.3,2.28,;14.1,3.6,;13.36,4.94,;11.76,2.32,;11.02,3.66,)|
Structure
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