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TargetTyrosyl-DNA phosphodiesterase 1 (TDP1)
LigandBDBM50397318
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864727
IC50 12000±n/a nM
Citation Sirivolu, VRVernekar, SKMarchand, CNaumova, AChergui, ARenaud, AStephen, AGChen, FSham, YYPommier, YWang, Z 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. J Med Chem55:8671-84 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Name:Tyrosyl-DNA phosphodiesterase 1
Synonyms:Tyrosyl-DNA phosphodiesterase 1
Type:Enzyme
Mol. Mass.:68430.66
Organism:Homo sapiens (Human)
Description:Q9NUW8
Residue:608
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50397318
NameBDBM50397318
Synonyms:CHEMBL2170123
TypeSmall organic molecule
Emp. Form.C12H8N2OS2
Mol. Mass.260.335
SMILESOC1=NC(=S)C(S1)=Cc1ccc2[nH]ccc2c1 |w:7.8,t:1|
Structure
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n/a