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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50397788
Substrate
n/a
Meas. Tech.
ChEMBL_874589 (CHEMBL2186225)
IC50
22000±n/a nM
Citation
 Ashwell, MA; Lapierre, JM; Brassard, C; Bresciano, K; Bull, C; Cornell-Kennon, S; Eathiraj, S; France, DS; Hall, T; Hill, J; Kelleher, E; Khanapurkar, S; Kizer, D; Koerner, S; Link, J; Liu, Y; Makhija, S; Moussa, M; Namdev, N; Nguyen, K; Nicewonger, R; Palma, R; Szwaya, J; Tandon, M; Uppalapati, U; Vensel, D; Volak, LP; Volckova, E; Westlund, N; Wu, H; Yang, RY; Chan, TC Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J Med Chem 55:5291-310 (2012) [PubMed]  Article 
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
  
Inhibitor
Name:
BDBM50397788
Synonyms:
CHEMBL2177818
Type:
Small organic molecule
Emp. Form.:
C25H20N6O
Mol. Mass.:
420.4659
SMILES:
Nc1ncccc1-c1nc2cccnc2n1-c1ccc(CC(=O)Nc2ccccc2)cc1
Structure:
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