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TargetCytosol aminopeptidase
LigandBDBM50397952
Substrate/Competitorn/a
Meas. Tech.ChEMBL_872713
Ki>100000±n/a nM
Citation Albrecht, SSalomon, EDefoin, ATarnus, C Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors. Bioorg Med Chem20:4942-53 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytosol aminopeptidase
Name:Cytosol aminopeptidase
Synonyms:LAP | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase
Type:Homohexamer
Mol. Mass.:56288.28
Organism:Bos taurus (bovine)
Description:Bovine kidney LAPc was purchased from Sigma Chemical Co.
Residue:519
Sequence:
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFN
KLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKEN
IRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGS
EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWI
EEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMD
LMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQV
DNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFE
ASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL
DIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
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BDBM50397952
NameBDBM50397952
Synonyms:CHEMBL2179979
TypeSmall organic molecule
Emp. Form.C17H17NOS
Mol. Mass.283.388
SMILESN[C@H]1CCc2ccccc2[C@@H](Sc2ccccc2)C1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a