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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50398022
Substrate
n/a
Meas. Tech.
ChEMBL_873176 (CHEMBL2183407)
IC50
1460±n/a nM
Citation
 Xiao, J; Westbroek, W; Motabar, O; Lea, WA; Hu, X; Velayati, A; Zheng, W; Southall, N; Gustafson, AM; Goldin, E; Sidransky, E; Liu, K; Simeonov, A; Tamargo, RJ; Ribes, A; Matalonga, L; Ferrer, M; Marugan, JJ Discovery of a novel noniminosugar acida glucosidase chaperone series. J Med Chem 55:7546-59 (2012) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
105312.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506060
Residue:
952
Sequence:
MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGASRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGAQMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPVEALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
  
Inhibitor
Name:
BDBM50398022
Synonyms:
CHEMBL2181097
Type:
Small organic molecule
Emp. Form.:
C19H19N3O5S
Mol. Mass.:
401.436
SMILES:
OC(=O)c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)Cc2c1
Structure:
Search PDB for entries with ligand similarity: