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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50398032
Substrate
n/a
Meas. Tech.
ChEMBL_873176 (CHEMBL2183407)
IC50
940±n/a nM
Citation
 Xiao, J; Westbroek, W; Motabar, O; Lea, WA; Hu, X; Velayati, A; Zheng, W; Southall, N; Gustafson, AM; Goldin, E; Sidransky, E; Liu, K; Simeonov, A; Tamargo, RJ; Ribes, A; Matalonga, L; Ferrer, M; Marugan, JJ Discovery of a novel noniminosugar acida glucosidase chaperone series. J Med Chem 55:7546-59 (2012) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
105312.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506060
Residue:
952
Sequence:
MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGASRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGAQMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPVEALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
  
Inhibitor
Name:
BDBM50398032
Synonyms:
CHEMBL1603014
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4S
Mol. Mass.:
399.463
SMILES:
CC(=O)c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)Cc2c1
Structure:
Search PDB for entries with ligand similarity: