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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM50398381
Substrate
n/a
Meas. Tech.
ChEMBL_875912 (CHEMBL2188025)
IC50
6±n/a nM
Citation
 Blake, JF; Xu, R; Bencsik, JR; Xiao, D; Kallan, NC; Schlachter, S; Mitchell, IS; Spencer, KL; Banka, AL; Wallace, EM; Gloor, SL; Martinson, M; Woessner, RD; Vigers, GP; Brandhuber, BJ; Liang, J; Safina, BS; Li, J; Zhang, B; Chabot, C; Do, S; Lee, L; Oeh, J; Sampath, D; Lee, BB; Lin, K; Liederer, BM; Skelton, NJ Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem 55:8110-27 (2012) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM50398381
Synonyms:
CHEMBL2177388
Type:
Small organic molecule
Emp. Form.:
C24H31ClFN5O
Mol. Mass.:
459.987
SMILES:
CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CF)c12)c1ccc(Cl)cc1 |r|
Structure:
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