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TargetOrotidine Monophosphate Decarboxylase (ODCase)
LigandBDBM50310540
Substrate/Competitorn/a
Meas. Tech.ChEMBL_874990
Ki 1200000±n/a nM
Citation Purohit, MKPoduch, EWei, LWCrandall, IETo, TKain, KCPai, EFKotra, LP Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J Med Chem55:9988-97 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Orotidine Monophosphate Decarboxylase (ODCase)
Name:Orotidine Monophosphate Decarboxylase (ODCase)
Synonyms:OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase
Type:Enzyme
Mol. Mass.:24909.45
Organism:Methanobacterium thermoautotrophicum
Description:n/a
Residue:228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
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  Blast E-value cutoff:
BDBM50310540
NameBDBM50310540
Synonyms:((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl dihydrogen phosphate | ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | CHEMBL307679 | CYTIDINE-5'-MONOPHOSPHATE | Phosphoric acid mono-[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester | cytidine 5'-phosphate
TypeSmall organic molecule
Emp. Form.C9H14N3O8P
Mol. Mass.323.1965
SMILESNc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a