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Target
Trehalase
Ligand
BDBM18355
Substrate
n/a
Meas. Tech.
ChEMBL_878839 (CHEMBL2184147)
IC50
38000±n/a nM
Citation
Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia. J Med Chem 55:10347-62 (2012) [PubMed] Article
More Info.:
Target
Name:
Trehalase
Synonyms:
Alpha,alpha-trehalase
Type:
PROTEIN
Mol. Mass.:
63480.07
Organism:
Rattus norvegicus
Description:
ChEMBL_208284
Residue:
557
Sequence:
ALSPLCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYYVPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPNVADRALKYLEDNKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNRIKTNFKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVTALLLSLLLQ
Inhibitor
Name:
BDBM18355
Synonyms:
(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL1029 | MIGLUSTAT | N-Butyl-DNJ | US20230339856, Compound NB-DNJ | US9181184, 5
Type:
Small organic molecule
Emp. Form.:
C10H21NO4
Mol. Mass.:
219.278
SMILES:
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO