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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50399771
Substrate
n/a
Meas. Tech.
ChEMBL_877370 (CHEMBL2182415)
Ki
22.1±n/a nM
Citation
 Mazurov, AA; Kombo, DC; Hauser, TA; Miao, L; Dull, G; Genus, JF; Fedorov, NB; Benson, L; Sidach, S; Xiao, Y; Hammond, PS; James, JW; Miller, CH; Yohannes, D Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. J Med Chem 55:9793-809 (2012) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50399771
Synonyms:
CHEMBL2179883
Type:
Small organic molecule
Emp. Form.:
C24H27N3O3
Mol. Mass.:
405.4895
SMILES:
CCOc1cccc2cc(oc12)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 |r,wU:15.16,wD:22.26,(27.02,-8.29,;26.13,-7.03,;26.77,-5.63,;25.87,-4.37,;26.5,-2.98,;25.6,-1.73,;24.08,-1.89,;23.46,-3.27,;21.99,-3.74,;21.99,-5.28,;23.44,-5.76,;24.35,-4.52,;20.83,-6.31,;20.83,-7.85,;19.5,-5.54,;18.16,-6.3,;16.83,-5.53,;15.5,-6.3,;15.5,-7.85,;16.83,-8.61,;16.05,-7.27,;17.42,-6.77,;18.16,-7.85,;19.5,-8.62,;19.49,-10.16,;18.16,-10.93,;18.15,-12.47,;19.49,-13.24,;20.83,-12.46,;20.82,-10.93,)|
Structure:
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