Reaction Details Report a problem with these data
Target
TGF-beta receptor type-2
Ligand
BDBM50399832
Substrate
n/a
Meas. Tech.
ChEMBL_877385 (CHEMBL2182430)
IC50
3970±n/a nM
Citation
 Schade, D; Lanier, M; Willems, E; Okolotowicz, K; Bushway, P; Wahlquist, C; Gilley, C; Mercola, M; Cashman, JR Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling. J Med Chem 55:9946-57 (2012) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM50399832
Synonyms:
CHEMBL2180272
Type:
Small organic molecule
Emp. Form.:
C32H32N2O3
Mol. Mass.:
492.6081
SMILES:
COC(=O)C1C(C2=C(CC(CC2=O)c2ccc(cc2)N(C)C)N=C1C)c1ccc(cc1)-c1ccccc1 |c:24,t:6|
Structure:
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