Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM50386790
Substrate
n/a
Meas. Tech.
ChEMBL_872312 (CHEMBL2187411)
EC50
>10000±n/a nM
Citation
 Negoro, N; Sasaki, S; Mikami, S; Ito, M; Suzuki, M; Tsujihata, Y; Ito, R; Harada, A; Takeuchi, K; Suzuki, N; Miyazaki, J; Santou, T; Odani, T; Kanzaki, N; Funami, M; Tanaka, T; Kogame, A; Matsunaga, S; Yasuma, T; Momose, Y Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist. ACS Med Chem Lett 1:290-294 (2010) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM50386790
Synonyms:
CHEMBL1829174 | CHEMBL2047159 | TAK-875
Type:
Small organic molecule
Emp. Form.:
C29H32O7S
Mol. Mass.:
524.625
SMILES:
Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Structure:
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