Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50400237
Substrate
n/a
Meas. Tech.
ChEMBL_872315 (CHEMBL2187414)
Ki
370±n/a nM
Citation
 Negoro, N; Sasaki, S; Mikami, S; Ito, M; Suzuki, M; Tsujihata, Y; Ito, R; Harada, A; Takeuchi, K; Suzuki, N; Miyazaki, J; Santou, T; Odani, T; Kanzaki, N; Funami, M; Tanaka, T; Kogame, A; Matsunaga, S; Yasuma, T; Momose, Y Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist. ACS Med Chem Lett 1:290-294 (2010) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50400237
Synonyms:
CHEMBL2179472
Type:
Small organic molecule
Emp. Form.:
C29H32O7S
Mol. Mass.:
524.625
SMILES:
Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@@H](CC(O)=O)COc3c2)c1 |r|
Structure:
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