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Target
Complement factor D
Ligand
BDBM50400275
Substrate
n/a
Meas. Tech.
ChEMBL_872411 (CHEMBL2188699)
IC50
3±n/a nM
Citation
 Abdel-Magid, AF Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett 3:781-782 (2012) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50400275
Synonyms:
CHEMBL2180766 | US9085555, 127
Type:
Small organic molecule
Emp. Form.:
C29H31ClFN5O5
Mol. Mass.:
584.038
SMILES:
CC(C)(C)OC(=O)Cc1ccc2c(NC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NCc3cccc(Cl)c3F)cn(C(N)=O)c2c1 |r|
Structure:
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