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Target
Serine/threonine-protein kinase 33
Ligand
BDBM50400664
Substrate
n/a
Meas. Tech.
ChEMBL_880288 (CHEMBL2216290)
IC50
14±n/a nM
Citation
 Weïwer, M; Spoonamore, J; Wei, J; Guichard, B; Ross, NT; Masson, K; Silkworth, W; Dandapani, S; Palmer, M; Scherer, CA; Stern, AM; Schreiber, SL; Munoz, B A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett 3:1034-1038 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM50400664
Synonyms:
CHEMBL2204239
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2S
Mol. Mass.:
389.47
SMILES:
CC(C)c1ccc(NC(=O)c2cccs2)c(c1)-c1nc2ccccc2[nH]c1=O
Structure:
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